Pharmacologic Management of Chronic Kidney Disease Across Stages

Chronic kidney disease alters drug absorption, distribution, metabolism, and excretion, increasing the risk for therapeutic failure, adverse drug events, and preventable progression when medications are not optimized to kidney function. This course focuses entirely on pharmacologic management across CKD stages, emphasizing evidence based renoprotective therapy and stage specific medication selection. Learners will integrate eGFR and albuminuria into prescribing decisions for RAAS blockade, SGLT2 inhibitors, nonsteroidal mineralocorticoid receptor antagonists, and cardio metabolic adjuncts, while also managing common complications such as hypertension and volume overload, hyperkalemia, metabolic acidosis, mineral and bone disorder, dyslipidemia, and anemia. Practical prescribing considerations include monitoring intervals, interaction management, use of potassium binders and bicarbonate therapy, anemia agents and iron strategies, and medication transitions as patients approach kidney replacement therapy or choose conservative management.