Ischemic stroke and transient ischemic attack are among the most time-sensitive conditions a nurse will encounter, and the quality of nursing recognition and management directly shapes whether a patient recovers function or lives with lasting disability. This 6.0 contact hour course offers a comprehensive review for LPNs, RNs, and APRNs, moving from the pathophysiology of cerebral ischemia through recognition and prehospital systems, emergency assessment and neuroimaging, intravenous thrombolysis, endovascular thrombectomy, acute stroke unit care, complications and prognosis, and secondary prevention. It emphasizes the work that falls to nursing, including establishing last known well, administering the NIH Stroke Scale, managing blood pressure and physiologic targets, screening for dysphagia, recognizing hemorrhagic transformation and cerebral edema, and supporting adherence and recovery after discharge. Case-based scenarios, reference tables, and branded figures reinforce practical application, equipping nurses to integrate current evidence-based practice, including the 2026 AHA/ASA guideline for the early management of acute ischemic stroke, into safe and confident bedside care.