Alpha-gal syndrome (AGS) is a tick-bite-associated allergic condition that has emerged rapidly across the United States, with more than 110,000 suspected cases documented between 2010 and 2022 and an estimated true burden that may exceed 450,000. Unlike classic food allergies, AGS produces reactions to a carbohydrate, galactose-alpha-1,3-galactose, found in beef, pork, lamb, and other mammalian products. Its hallmark is a delayed onset of symptoms two to eight hours after ingestion, a pattern that frequently wakes patients in the middle of the night and leads clinicians away from a food allergy diagnosis. Compounding the challenge, a national survey found that 42 percent of health care providers had never heard of the condition. This course gives LPNs, RNs, and APRNs a thorough, practice-focused understanding of AGS, including the immunology that drives it, the role of the lone star tick and other species, the spectrum of clinical presentations from isolated gastrointestinal distress to anaphylaxis, the diagnostic workup and its pitfalls, and the cornerstones of management: dietary avoidance, anaphylaxis preparedness, medication and perioperative considerations, and tick-bite prevention. Learners will finish prepared to shorten the long diagnostic delays many patients experience and to deliver confident, compassionate patient education.